Sign in

Genetics

Charlie (two En copies)

Charlie (two En copies) · En/En About English Spotting (En)

Two copies are recorded for this trait.

Incomplete dominant

How do you know?

Appearance reported by owner

Reported risk: Two copies (charlie) are reported to cause megacolon syndrome: the large bowel slows and enlarges, leading to constipation, weight loss and early death in some rabbits, usually with age. One copy (broken) was not affected.

Fontanesi L, Vargiolu M, Scotti E, Latorre R, Faussone Pellegrini MS, Mazzoni M, Asti M, Chiocchetti R, Romeo G, Clavenzani P, De Giorgio R 2014, The KIT gene is associated with the English spotting coat color locus and congenital megacolon in Checkered Giant rabbits (Oryctolagus cuniculus), PLoS One 9(4):e93750Bödeker D, Türck O, Lovén E, Wieberneit D, Wegner W 1995, Pathophysiological and functional aspects of the megacolon-syndrome of homozygous spotted rabbits, Zentralblatt für Veterinärmedizin A 42(9):549-559Gerlitz S, Wessel G, Wieberneit D, Wegner W 1993, [The problems of breeding spotted rabbits. 3. Variability of the pigmentation grade, ganglionic intestinal wall supply, relationship to pathogenesis], Deutsche Tierärztliche Wochenschrift 100(6):237-239Wieberneit D, Mahdi N, Zacharias K, Wegner W 1991, [The problems of spotted breeds of rabbits. 1. Fattening and body condition at slaughter, organ parameters], Deutsche Tierärztliche Wochenschrift 98(9):352-354Mahdi N, Wieberneit D, Wegner W 1992, [The problem of breeding for spots in rabbits. 2.], Deutsche Tierärztliche Wochenschrift 99(3):111-113Flemming K, Kühnel C, Wieberneit D, Wegner W 1994, [The problems of spotted breeds of rabbits. 4. Morpho- and histometric findings in the CNS and thyroid glands...], Deutsche Tierärztliche Wochenschrift 101(11):434-439Wieberneit D, Wegner W 1995, Albino rabbits can suffer from megacolon-syndrome when they are homozygous for the 'English spot' gene (EnEn), World Rabbit Science 3(1):19-26Fontanesi L 2021, Rabbit genetic resources can provide several animal models to explain at the genetic level the diversity of morphological and physiological relevant traits, Appl Sci 11:373Bödeker D, Türck O, Lovén E, Wieberneit D, Wegner W 1995, Pathophysiological and functional aspects of the megacolon-syndrome of homozygous spotted rabbits, Zentralblatt für Veterinärmedizin A 42(9):549-559
English Spotting (En) example
Example · AI illustration
Appearance varies