Shortcuts
Learn About
Find Breeders
Genetics
One cream copy, Dun (one or two copies), Gray (zygosity unknown), Tobiano (one or two copies), Silver (one or two copies)
Recorded as showing this trait.
Incomplete dominant
How do you know?
Appearance reported by owner
Recorded as showing this trait. One or two copies are not known.
Dominant
How do you know?
Appearance reported by owner
Recorded as showing this trait. One or two copies are not known.
Dominant
How do you know?
Appearance reported by owner
Reported risk: Population studies report dermal melanomas in about two thirds to three quarters of gray horses over 15, often under the tail and around the head.
Fleury C, Berard F, Leblond A, Faure C, Ganem N, Thomas L (2000) Pigment Cell Res 13:47-51, The study of cutaneous melanomas in Camargue-type gray-skinned horses (2): epidemiological surveySeltenhammer MH, Simhofer H, Scherzer S, Zechner R, Curik I, Solkner J, et al. (2003) Equine Vet J 35:153-157, Equine melanoma in a population of 296 grey Lipizzaner horsesRosengren Pielberg G, Golovko A, Sundstrom E, ... Solkner J, Andersson L (2008) Nat Genet 40:1004-1009, A cis-acting regulatory mutation causes premature hair graying and susceptibility to melanoma in the horseReported risk: Gray horses have been reported to be overrepresented among cases of ocular squamous cell carcinoma. This is a coat-color association; a causal effect of the gray allele has not been established.
Crausaz M, Launois T, Smith-Fleming K, McCoy AM, Knickelbein KE, Bellone RR 2020, Genes (Basel), DDB2 Genetic Risk Factor for Ocular Squamous Cell Carcinoma Identified in Three Additional Horse BreedsDugan SJ, Curtis CR, Roberts SM, Severin GA 1991, J Am Vet Med Assoc 198:251-256, Epidemiologic study of ocular/adnexal squamous cell carcinoma in horsesUC Davis Veterinary Genetics Laboratory, Gray Copy Number (VGL test page)Recorded as showing this trait. One or two copies are not known.
Dominant
How do you know?
Appearance reported by owner
Recorded as showing this trait. One or two copies are not known.
Dominant
How do you know?
Appearance reported by owner
Reported risk: Multiple congenital ocular anomalies have been reported with one or two silver copies, including in chestnut horses. One-copy horses generally have milder findings; two-copy horses tend to have more severe abnormalities that can affect vision.
Andersson LS, Wilbe M, Viluma A, Cothran G, Ekesten B, Ewart S, Lindgren G (2013) PLoS ONE 8:e75639, Equine Multiple Congenital Ocular Anomalies and Silver Coat Colour Result from the Pleiotropic Effects of Mutant PMELKomaromy AM, Rowlan JS, La Croix NC, Mangan BG (2011) Vet Ophthalmol, Equine Multiple Congenital Ocular Anomalies (MCOA) syndrome in PMEL17 (Silver) mutant ponies: five casesUC Davis Veterinary Genetics Laboratory, Multiple Congenital Ocular Anomalies (MCOA) (VGL test page)Andersson LS, Wilbe M, Viluma A, Cothran G, Ekesten B, Ewart S, Lindgren G (2013) PLoS ONE 8:e75639, Equine Multiple Congenital Ocular Anomalies and Silver Coat Colour Result from the Pleiotropic Effects of Mutant PMELKomaromy AM, Rowlan JS, La Croix NC, Mangan BG (2011) Vet Ophthalmol, Equine Multiple Congenital Ocular Anomalies (MCOA) syndrome in PMEL17 (Silver) mutant ponies: five casesUC Davis Veterinary Genetics Laboratory, Multiple Congenital Ocular Anomalies (MCOA) (VGL test page)Andersson LS, Wilbe M, Viluma A, Cothran G, Ekesten B, Ewart S, Lindgren G (2013) PLoS ONE 8:e75639, Equine Multiple Congenital Ocular Anomalies and Silver Coat Colour Result from the Pleiotropic Effects of Mutant PMELKomaromy AM, Rowlan JS, La Croix NC, Mangan BG (2011) Vet Ophthalmol, Equine Multiple Congenital Ocular Anomalies (MCOA) syndrome in PMEL17 (Silver) mutant ponies: five casesUC Davis Veterinary Genetics Laboratory, Multiple Congenital Ocular Anomalies (MCOA) (VGL test page)
